Science & innovation
A new technology for a new care approach
NostraBiome builds frontier biology models, informed by clinical research in digestive disease, cancer supportive care and metabolic health. The goal is to estimate a changing biological state, not just explain an isolated test result.
Frontier biology models
From a snapshot to a changing biological state.
Treatment starts in the clinic. Response happens in real life. NostraBiome’s frontier biology models connect the two by bringing multi-omic measurements, medical history, symptoms and daily signals onto one timeline. The care cycle — Understand → Guide → Observe → Learn → Adapt — is informed by the data that makes you unique. Models are designed to estimate state, track response and carry uncertainty explicitly, helping inform guidance between medical checkpoints. Medical decisions remain with your clinician.
This describes the modeling approach and ongoing development, not a claim that every model or inferred biomarker has been clinically validated.
01 · Partial observability
State estimation, not lab-report interpretation.
Every measurement is treated as a noisy observation of a latent state rather than ground truth. The estimate is updated sequentially as new data arrives, and uncertainty is carried explicitly: a recommendation is issued only when the uncertainty band is tight enough to support it.
02 · Methods
What is actually measured, and how it becomes a decision.
These are the layers used in the published clinical programmes. Full protocols, endpoint definitions and statistical analysis are in the papers themselves.
Metagenomics
Taxonomic composition and functional potential of the gut microbiota, from sequencing.
Metabolomics & transcriptomics
Used in the paediatric cohort to connect composition to actual biological activity.
Clinical biomarkers
hs-CRP, faecal calprotectin and metabolic panels — objective endpoints, not self-report.
Longitudinal phenotype
Symptoms, bowel habit, energy, sleep, nutrition — captured structurally, not episodically.
State estimation
A sequential model that fuses the layers into an estimate with uncertainty, updated on every observation.
Response verification
Every intervention is re-measured: the outcome becomes a training label, not only a clinical result.
03 · Multi-omics
Four layers. Four cadences.
Each layer answers a different question and moves at a different rate. Together they describe the same person, at the same hour, from four angles.
Genome
What is possible
Stable for life
Microbiome
Who lives inside you
Shifts in days
Biomarkers
How it runs right now
Shifts in weeks
Phenotype
How you feel today
Shifts in hours
04 · Trajectory
Drift becomes a symptom if you hear it too late.
Bodies rarely break suddenly. They slide. The model tracks the trajectory rather than the point, and marks the window in which a gentle intervention — nutrition, supplements, rhythm — can still change direction.
05 · Genetics
Genetics sets the context, not the verdict.
Your variants are rules of play: what you metabolise easily, where you need support, which protocol has a real chance of working for you. They set the prior; daily signals correct it.
06 · The closed loop
Measure. Understand. Adjust. Re-evaluate.
We measure, estimate the state, adjust, then listen again to the result of that adjustment. Every round makes the next recommendation sharper. That is the product, reduced to its essence.
07 · Conversation
You talk to it like a human. It extracts the signals underneath.
You say “I feel bloated after dinner” or “my energy drops in the afternoon”, and the model turns every sentence into structured data: which biological layer is affected, which direction it is moving, and what to adjust. The interface is human; the reasoning behind it is multi-omic.
Illustrative · live extraction
I've been feeling tired for the last two weeks. Bloated in the evening after bread and pasta.
The signal points to a drift in fermentation. Here's what we can adjust.
- Microbiome
- raised fermentation · lower diversity
- Biomarkers
- post-meal glucose · gut inflammation
- Phenotype
- evening bloating · fatigability
- Adjustment
- FODMAP reduction · carb timing · targeted prebiotic
08 · Applicability
Where it changes outcomes.
Digestive disease
Modulating the microbiome and host environment before symptoms escalate.
Oncology care
Tracking tolerance, immune response and adverse effects to keep treatment on course.
GLP-1 therapies
Adapting nutrition and supplements to stage, dose and individual response.
Longevity
Slowing biological drift through small, repeated interventions verified over time.
Published programmes are prospective and real-world cohort studies without a randomised control arm. An IBS study (344 participants) is ongoing and not yet peer-reviewed; no conclusion should be drawn until publication.
1,200+
patients studied across clinical programs
>70%
of refractory IBD patients reported feeling “much improved” at 3 months
>85%
of cases showed reductions in hs-CRP and faecal calprotectin, as reported by NostraBiome
Results reported across NostraBiome’s research programmes. Individual results vary. Review the clinical studies and their limitations.
The DeepGene test
Your microbiome and your human DNA. From one sample.
DeepGene is a shotgun metagenomic test from a single stool sample. Unlike common tests that read one gene, it reads all the DNA in the sample — identifying organisms down to strain level, the genes they actually carry, fungi and viruses, and your own human DNA.
Microbial DNA
Bacteria · archaea · fungi · viruses · their functional genes
Human DNA
Predispositions · DNA integrity · intestinal lining
What you receive
A report built from measurements, not assumptions.
Composition
Every organism identified from phylum to strain — bacteria, archaea, fungi and viruses — each compared with a control range.
Function
What your microbial community can actually produce: short-chain fatty acids, B vitamins, neurotransmitter precursors and metabolites you would rather see less of.
Ecosystem indices
Diversity, balance and key species that describe the overall state of your gut.
Human DNA
Genetic predispositions, DNA integrity and the state of the intestinal lining — read from the same sample.
Certified & regulated
Medical-grade, from lab to software.
- ISO 13485 certified quality management.
- EU MDR 2017/745 CE-marked medical device software, registered in EUDAMED.
- Published clinical studies reviewed by specialists.
- Nostra complements your doctor. Medical decisions remain with your care team.